Mouse CD39 / ENTPD2 Protein

• Catalog Number: orb867339
• Category: Proteins
• Description: CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
• Reactivity: Mouse
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 51.7 kDa
• Target: CD39
• Protein Sequence: NP_033978.1
• Source: Mouse CD39, His Tag (orb867339) is expressed from human 293 cells (HEK293). It contains AA Thr 38 -Ile 478 (Accession # P55772-1).
• Expression System: HEK293
• Expression Region: Thr 38 -Ile 478
• Endotoxins: 1.0 EU per μg
• NCBI: NP_033978.1
• Storage: -20℃
• Buffer/Preservatives: 20mM Tris, 150mM NaCl, pH8.0
• Alternative names: CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-A
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 51.7 kDa. The protein migrates as 66-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.