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Mouse B7-1 / CD80 Protein
Catalog Number: orb383532
| Catalog Number | orb383532 |
|---|---|
| Category | Proteins |
| Description | B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
| Reactivity | Mouse |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 25.6 kDa |
| Target | B7-1 |
| Protein Sequence | Val 38 - Lys 245 |
| Source | Mouse B7-1, His Tag (orb383532) is expressed from human 293 cells (HEK293). It contains AA Val 38 - Lys 245 (Accession # Q00609-1). |
| Expression System | HEK293 |
| Expression Region | Val 38 - Lys 245 |
| Endotoxins | 1.0 EU per μg |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7 Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.6 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse B7-1 protein
- Item 1 of 1
Mouse B7-1 / CD80 Protein [orb257961]
Unconjugated
95%
50.3 kDa
Mouse B7-1, Fc Tag (orb257961) is expressed from human 293 cells (HEK293). It contains AA Val 38 - Lys 245 (Accession # Q00609-1).
1 mg, 100 μg 
Recombinant Mouse B7-1/Cd80 Protein, His Tag [orb1552877]
≥90% as determined by SDS-PAGE
This protein contains the mouse Cd80(Val38-Asn246) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Mouse B7-1/Cd80 Protein, Fc Tag [orb1552878]
≥90% as determined by SDS-PAGE
This protein contains the mouse Cd80(Val38-Lys245) was fused with the C-terminal Fc Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Mouse B7-1/CD80 Protein, His Tag [orb1551129]
> 92% by SDS-PAGE.
KMP1358, Recombinant Mouse B7-1/CD80 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Val38-Lys245) of mouse B7-1/CD80 (Accession #NP_033985.3) fused with a 6×His Tag at the C-terminus.
50 μg, 100 μgRecombinant Mouse B7-1/CD80 Protein, Fc & His Tag [orb1551130]
> 97% by SDS-PAGE.
KMP1357, Recombinant Mouse B7-1/CD80 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Val38-Lys245) of mouse B7-1/CD80 (Accession #NP_033985.3) fused with a Fc, 6×His Tag at the C-terminus.
50 μg, 100 μg
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