ML355

SKU: orb1223272

Description

ML355 is a potent and selective inhibitor of human 12-lipoxygenase.

Key Properties

• CAS Number: 1532593-30-8
• MW: 441.52
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₉N₃O₄S₂
• SMILES: COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
• Target: 12-Lipoxygenase
• Solubility: DMSO : ≥ 42 mg/mL. 95.13 mM

Bioactivity

• In Vivo:
  ML355 (1.88-30 mg/kg; i. g. ; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal model: C57BL/6 mice. Dosage: 1.88, 3.75, 7.5, 15, 30 mg/kg. Administration: Oral gavage; 2 times per day for two days. Result: The thrombus formation in mice was strongly inhibited by higher doses of ML355.
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• In Vitro:
  ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML355 | ML 355 | ML-355

Quick Database Links

Gene Symbol

12-Lipoxygenase