ML239

SKU: orb1302890

Description

ML239 (CID-49843203) is a selective small molecule inhibitor targeting breast cancer stem cells, demonstrating potent activity with an IC50 of 1.16 μM. It is a valuable research tool for investigating stem cell biology and tumorigenesis in both in vitro and in vivo experimental models.

Key Properties

• CAS Number: 1378872-36-6
• MW: 346.6
• Purity: 99.82% (May vary between batches)
• Formula: C₁₃H₁₀Cl₃N₃O₂
• SMILES: Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1
• Target: Others
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (7.21 mM);DMSO:50 mg/mL (144.26 mM);Ethanol:50 mM

Bioactivity

• Target IC50:
  Breast cancer stem cells:1.16 μM.
• In Vitro:
  ML239 (Compound 7j) serves as a powerful and selective inhibitor targeting breast cancer stem cells, exhibiting an IC50 value of 1.16 μM and demonstrating approximately 24-fold greater selectivity compared to the control cell line. It operates primarily by potentially activating fatty acid desaturase 2 (FADS2), thereby inhibiting the growth of breast cancer stem-like cells. Additionally, ML239 shows cytotoxic effects on NCIH661 cells. Interestingly, the reduction of FADS2 activity, either through direct knockdown or by using the FADS2 inhibitor SC-26196, diminishes the cytotoxicity of ML239 in cancer cell lines (CCLs), suggesting a critical role of FADS2 in ML239's mechanism of action.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CID 49843203, CID49843203, CID-49843203, inhibit, ML 239, ML239, ML-239, Inhibitor

Compound Identifiers

PubChem CID

135999136