ML239

SKU: orb1223327

Description

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

Key Properties

• CAS Number: 1378872-36-6
• MW: 346.59
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₀Cl₃N₃O₂
• SMILES: Clc2cc(Cl)cc(Cl)c2OCC(=O)N\N=C\c1cccn1
• Target: mTOR
• Solubility: DMSO : ≥ 300 mg/mL 865.55 mM

Bioactivity

• In Vitro:
  ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

mTOR