Mitiglinide calcium hydrate

SKU: orb1225714

Description

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells; has potent hypoglycemic effects.Diabetes Approved(In Vitro):Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.(In Vivo):Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 207844-01-7
• MW: 353.46
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₅NO₃ . 1/2 Ca . H₂O
• SMILES: C1CC[C@H]2CN(C[C@H]2C1)C(=O)C[C@H](CC3=CC=CC=C3)C(=O)[O-].C1CC[C@H]2CN(C[C@H]2C1)C(=O)C[C@H](CC3=CC=CC=C3)C(=O)[O-].O.O.[Ca+2]
• Target: Potassium Channel
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. Animal model: Pregnant Wistar rats (12 weeks). Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg. Administration: Oral administration. Result: Dose-dependently suppressed AUCglucose levels.
• In Vitro:
  Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KAD-1229 calcium hydrate | S-21403 calcium hydrate

Quick Database Links

Gene Symbol

Potassium Channel