Mithramycin A

SKU: orb1225860

Description

A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; binds to the minor groove of DNA at GC-rich sites, induces cancer cell apoptosis and metastasis.

Key Properties

• CAS Number: 18378-89-7
• MW: 1085
• Purity: >98% (HPLC)
• Formula: C₅₂H₇₆O₂₄
• SMILES: O=C1[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@@H](O[C@H]4C[C@](C)(O)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[C@H](O)[C@@H](C)O2)[C@H]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)CC5=C1C(O)=C6C(O)=C(C)C(O[C@H]7C[C@@H](O[C@H]8C[C@@H](O)[C@H](O)[C@@H](C)O8)[C@H](O)[C@@H](C)O7)=CC6=C5
• Target: DNA/RNA Synthesis
• Solubility: In Vitro: DMSO : ≥ 100 mg/mL (92.15 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Plicamycin | PA 144 | NSC 24559

Quick Database Links

Gene Symbol

DNA/RNA Synthesis