Mirogabalin

SKU: orb1299969

Description

Mirogabalin (DS5565) is a selective α2δ-1 ligand calcium channel blocker developed for its analgesic properties. It is utilized in research on neuropathic pain models, with studies demonstrating efficacy in both in vitro binding assays and in vivo animal models of chronic pain.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1138245-13-2
• MW: 209.28
• Purity: 99.89%
• Formula: C₁₂H₁₉NO₂
• SMILES: CCC1=C[C@@H]2[C@@H](C[C@]2(CN)CC(O)=O)C1
• Target: Calcium Channel
• Solubility: DMSO:1.83 mg/mL (8.74 mM)

Bioactivity

• In Vivo:
  Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin . Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DS-5565, DS5565, DS 5565, CalciumChannel, Ca channels, Ca2+ channels, Calcium Channel, inhibit, Mirogabalin, Inhibitor, α2δ calcium channels

Compound Identifiers

PubChem CID

59509752