Mirin

SKU: orb2664830

Description

Mirin is a cell-permeable inhibitor of the MRN complex that suppresses ATM activation and Mre11 exonuclease activity, thereby blocking DNA double-strand break repair and inducing G1 phase arrest. It is widely used in vitro to study DNA damage response pathways, cell cycle checkpoints, and radiosensitization.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 299953-00-7
• MW: 220.25
• Purity: 99.24% (May vary between batches)
• Formula: C₁₀H₈N₂O₂S
• SMILES: O=C1N=C(SC1=CC2=CC=C(O)C=C2)N
• Target: ATM/ATR
• Solubility: DMF:60 mg/mL (272.42 mM)

Bioactivity

• In Vitro:
  Mirin inhibits H2AX phosphorylation with an IC5​​0 value of 66 μM. Mirin inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2 as well as MRN-dependent ATM autophosphorylation at Ser1981 in response to DSBs. Mirin treatment (50, 100 μM) of TOSA4 cells induced a significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

Compound Identifiers

PubChem CID

137705390