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Catalog Number | orb1089360 |
---|---|
Category | Small Molecules |
Description | Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma. |
CAS Number | [1313883-00-9] |
MW | 468.980603933334 |
SMILES | Cl.NC1(C2C=CC(=CC=2)N2C(C3=CC=CN=C3N)=NC3C=CC(C4C=CC=CC=4)=NC2=3)CCC1 |
Formula | C27H25CLN6 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
98.00% | |
1313883-00-9 | |
468.98 | |
C27H25ClN6 |
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