Milrinone

SKU: orb1309788

Description

Milrinone (Win 47203) is a selective phosphodiesterase 3 (PDE3) inhibitor used in cardiovascular research. It is applied in vitro and in vivo to study cardiac contractility and vasodilation, primarily for investigating heart failure and pulmonary hypertension mechanisms.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 78415-72-2
• MW: 211.22
• Purity: 99.93% (May vary between batches)
• Formula: C₁₂H₉N₃O
• SMILES: CC1=C(C=C(C#N)C(=O)N1)C=2C=CN=CC2
• Target: PDE
• Solubility: DMSO:62.5 mg/mL (295.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.47 mM)

Bioactivity

• Target IC50:
  PDE2:5.2 μM|PDE3:2.1 μM
• In Vivo:
  Milrinone is a potent (IC50: 0.16-0.90 μM) and selective (100-fold more potent than peak I) inhibitor of peak III. Milrinone markedly increased cAMP levels and was accompanied by marked vasodilation. The increase in cAMP levels in rabbit coronary artery smooth muscle cells was also concentration-dependent. The concentration-dependent increase in cAMP levels was similar in rabbit and human platelets.Milrinone inhibited human platelet aggregation (IC50: 2 mM). Milrinone increased intracellular cyclic AMP concentrations through an inhibitory effect on type III phosphodiesterase.
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• In Vitro:
  Milrinone is a potent (IC50: 0.16-0.90 μM) and selective (100-fold more potent than peak I) inhibitor of peak III. Milrinone markedly increased cAMP levels and was accompanied by marked vasodilation. The increase in cAMP levels in rabbit coronary artery smooth muscle cells was also concentration-dependent. The concentration-dependent increase in cAMP levels was similar in rabbit and human platelets.Milrinone inhibited human platelet aggregation (IC50: 2 mM). Milrinone increased intracellular cyclic AMP concentrations through an inhibitory effect on type III phosphodiesterase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Milrinone, PDE2, PDE3, Inhibitor, Win 47203, Win47203, Win-47203, phosphodiesterase, Phosphodiesterase (PDE)

Compound Identifiers

PubChem CID

4197