MF63

SKU: orb2695750

Description

MF63 is a potent and selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating low nanomolar IC50 values against both porcine and human enzymes. This small molecule is a valuable research tool for investigating the role of PGE2 in inflammation, pain, and fever, with utility in both in vitro biochemical assays and in vivo disease model studies.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 892549-43-8
• MW: 378.81
• Formula: C₂₃H₁₁ClN₄
• SMILES: Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N
• Target: Others,PGE Synthase
• Solubility: DMSO:43 mg/mL (113.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.28 mM)

Bioactivity

• In Vitro:
  MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme, in rodent species. mPGES-1 MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. The compound selectively inhibited the synthesis of PGE(2) when tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MF 63, MF63, MF-63

Compound Identifiers

PubChem CID

16070041