Mertansine

• Catalog Number: orb1306817
• Category: Small Molecules
• Description: Mertansine
• Purity: 99.76%
• MW: 738.29
• Biological Activity: Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
• CAS Number: [139504-50-0]
• Formula: C₃₅H₄₈ClN₃O₁₀S
• SMILES: CO[C@@H]1\C=C/C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCS)[C@@]2(C)O[C@H]2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
• Storage: -20°C
• Note: For research use only