Meropenem trihydrate

SKU: orb1219046

Description

Meropenem trihydrate with broad-spectrum antibacterial activity,is a carbapenem antibiotic.(In Vitro):Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.(In Vivo):Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection.

Key Properties

• CAS Number: 119478-56-7
• MW: 437.51
• Purity: >98% (HPLC)
• Formula: C₁₇H₃₁N₃O₈S
• SMILES: O=C(C(N12)=C(S[C@@H]3CN[C@H](C(N(C)C)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.[H]O[H].[H]O[H].[H]O[H]
• Target: Antibacterial
• Solubility: DMSO:90 mg/mL (205.71 mM; Need ultrasonic); H2O:12 mg/mL (27.43 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection. Animal model: Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis. Dosage: 60 mg/kg. Administration: Intraperitoneal injection; once. Result: Significantly reduced the incidence of pancreatic infection.
• In Vitro:
  Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SM 7338 trihydrate

Quick Database Links

Gene Symbol

Antibacterial