Mepazine

SKU: orb1308049

Description

Mepazine (Pecazine) is a potent, selective MALT1 protease inhibitor, demonstrating IC50 values of 0.83 μM and 0.42 μM against full-length and truncated forms, respectively. It is a valuable research tool for studying NF-κB signaling, lymphocyte activation, and inducing apoptosis in various lymphoma cell lines in vitro.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 60-89-9
• MW: 310.46
• Purity: 99.99% (May vary between batches)
• Formula: C₁₉H₂₂N₂S
• SMILES: CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
• Target: Apoptosis,MALT
• Solubility: DMSO:25 mg/mL (80.53 mM)

Bioactivity

• In Vivo:
  In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration.
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• In Vitro:
  Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABC-DLBCL, Apoptosis, B cell, diffuse, Inhibitor, MALT1, Mepazine, large, mucosa associated lymphoid tissue lymphoma translocation gene 1, inhibit, lymphoma, Pecazine

Compound Identifiers

PubChem CID

6075