Mc-Val-Cit-PAB-Cl

• Catalog Number: orb1307356
• Category: Small Molecules
• Description: Mc-Val-Cit-PAB-Cl
• Purity: 99.79%
• MW: 591.1
• Biological Activity: Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.
• CAS Number: 1639351-92-0
• Formula: C₂₈H₃₉ClN₆O₆
• SMILES: [C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O
• Storage: -20°C
• Note: For research use only