LXR alpha Antibody

• Catalog Number: orb1731735
• Category: Antibodies
• Description: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
• Species/Host: Rabbit
• Clonality: Monoclonal
• Tested applications: IHC, WB
• Reactivity: Human, Rat
• Isotype: Rabbit IgG
• Immunogen: A synthetic peptide of human LXR alpha
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000; IHC: 1/50-1/100
• Conjugation: Unconjugated
• MW: Calculated MW: 50 kDa; Observed MW: 50 kDa
• Entrez: 10062
• UniProt ID: Q13133
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin
• Alternative names: NR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver
• Note: For research use only
• Expiration Date: 12 months from date of receipt.