Lubiprostone (hemiketal)

• Catalog Number: orb1089770
• Category: Small Molecules
• Description: Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).
• CAS Number: [333963-40-9]
• MW: 390.46
• SMILES: CCCCC([C@]1(CC[C@@H]2[C@@H](CCCCCCC(=O)O)C(=O)C[C@H]2O1)O)(F)F
• Formula: C₂₀H₃₂F₂O₅
• Note: For research use only
• Expiration Date: 12 months from date of receipt.