Loganin

SKU: orb1305061

Description

Loganin is an iridoid glucoside that acts as a cyclooxygenase-1 (COX-1) inhibitor and suppresses TNF-α production. It exhibits antioxidant free-radical-scavenging activity and inhibits melanogenesis, making it a compound of interest for research in inflammation, oxidative stress, and dermatology.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 18524-94-2
• MW: 390.38
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₂₆O₁₀
• SMILES: COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]2[C@@H](C)[C@@H](O)C[C@H]12
• Target: Interleukin,BACE,TNF,ROS,Cholinesterase (ChE),NF-κB,Apoptosis,AChR
• Solubility: DMSO:250 mg/mL (640.4 mM);H2O:20 mg/mL (51.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM)

Bioactivity

• Target IC50:
  AChE:3.95 μM|BACE1:47.97 μM|BChE:33.02 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BACE1, BChE, Apoptosis, AChE, Inhibitor, Loganin, Loganoside, inhibit, NF-κB, NFkB, NFκB, NF-kB

Compound Identifiers

PubChem CID

87691