Lodoxamide

SKU: orb1302752

Description

Lodoxamide is a mast cell stabilizer used as an antiallergic agent. It is applied in research models of asthma and allergic conjunctivitis, with studies demonstrating its efficacy in both in vitro mast cell inhibition and in vivo animal models of allergic inflammation.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53882-12-5
• MW: 311.63
• Purity: 99.96% (May vary between batches)
• Formula: C₁₁H₆ClN₃O₆
• SMILES: OC(=O)C(=O)Nc1cc(cc(NC(=O)C(O)=O)c1Cl)C#N
• Target: Histamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.59 mM);DMSO:250 mg/mL (802.23 mM)

Bioactivity

• In Vivo:
  Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anaesthetized rhesus monkeys . Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation decreased microvascular permeability, and increased compliance .
• In Vitro:
  Lodoxamide effectively inhibits histamine release induced by compound 48/80 and reduces 45Ca influx triggered by ionophores, accompanied by a decrease in histamine release in purified rat peritoneal mast cells . Moreover, it significantly and dose-dependently suppresses eosinophil chemotaxis towards fMLP and IL-5. Additionally, Lodoxamide robustly inhibits the release of eosinophil peroxidase following IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

U-42585E, Inhibitor, Lodoxamide, Lodoxamidum, inhibit, HistamineReceptor, Histamine Receptor

Compound Identifiers

PubChem CID

44564