LMCD1 Protein, Human, Recombinant (His)

• Catalog Number: orb1960976
• Category: Proteins
• Description: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
• Tag: N, C-6xHis
• Purity: 98.00%
• MW: 45 KDa (reducing condition)
• UniProt ID: Q9NZU5
• Protein Sequence: Met1-Ser365
• Expression System: E. coli
• Biological Origin: Human
• Biological Activity: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
• Expression Region: Met1-Ser365
• Storage: -20°C
• Note: For research use only
• Application notes: 0
• Expiration Date: 6 months from date of receipt.