LL-K12-18

SKU: orb2664307

Description

LL-K12-18 is a molecular glue that stabilizes the interaction between CDK12 and DDB1, leading to Cyclin K degradation. This compound suppresses transcription and proliferation in cancer cells, serving as a valuable chemical probe for studying CDK12/cyclin K biology and targeted protein degradation in oncology research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• Target: PROTAC Linker,Molecular Glues,CDK
• Molecular Weight: 559.49
• Purity: 98.08%
• Formula: C₂₅H₃₂Cl₂N₁₀O
• SMILES: CCN1C2=NC(N3CCN(C(CN(CC)CC)=O)CC3)=NC(NCC4=NC5=CC(Cl)=C(Cl)C=C5N4)=C2N=C1

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172636053