Lipid III-45

• Catalog Number: orb1910463
• Category: Small Molecules
• Description: Lipid III-45 is an ionizable cationic lipid (pKa = 6.25).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1,2,3 LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.1,2 LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.3
• CAS Number: [2096984-25-5]
• MW: 724.2
• SMILES: O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
• Formula: C₄₅H₈₉NO₅
• Note: For research use only
• Expiration Date: 12 months from date of receipt.