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Catalog Number | orb1568377 |
---|---|
Category | Small Molecules |
Description | LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc mRNA). While both lipid 274 LNP RBD-hFc mRNA and lipid 14 LNP RBD-hFc mRNA induced equal cellular and humoral responses in mice at an mRNA dose of 5 μg, only lipid 14 LNP RBD-hFc mRNA exhibited strong immunogenicity following intradermal administration. Both intradermal administration and intramuscular administration of lipid 14 LNPs could activate antigen presenting cells (APCs), thus inducing cellular responses. |
CAS Number | [2430034-05-0] |
MW | 907.48 |
SMILES | O=C(OCCN(CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCN(C)C |
Formula | C56H110N2O6 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Chemical structure of orb1568377
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