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| Catalog Number | orb153620 |
|---|---|
| Category | Small Molecules |
| Description | Linsitinib, Free Base. Linsitinib is also known as OSI-906, is a novel, potent small-molecule dual insulin-like growth factor-1 receptor (IGF-1R)/insulin receptor (IR) kinase inhibitor. Linsitinib inhibited IGF-1R and IR kinases with IC50 values of 35 nM and 75 nM, respectively. Linsitinib showed superior efficacy compared with MAB391, a selective anti-IGF-1R antibody, in human tumor xenograft models in which both IGF-1R and IR were phosphorylated. |
| CAS Number | 867160-71-2 |
| Note | For research use only |
| Application notes | LNS |
| Expiration Date | 12 months from date of receipt. |
Chemical structure of Linsitinib, Free Base
Linsitinib, Free Base: OSI-906, OSI-906AA, OSI906, ASP-7487
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