L-Ascorbic acid sodium salt

SKU: orb1300567

Description

L-Ascorbic acid sodium salt

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 134-03-2
• MW: 198.11
• Purity: >99.99% (May vary between batches)
• Formula: C₆H₇NaO₆
• SMILES: [O-]C[C@@H]([C@]1([H])C(O)=C(C(O1)=O)O)O.[Na+]
• Target: Endogenous Metabolite,Reactive Oxygen Species,ROS,Calcium Channel,Apoptosis
• Solubility: DMSO:6.25 mg/mL (31.55 mM);H2O:198.9 mM

Bioactivity

• In Vivo:
  Tg rats treated with sodium L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium L-ascorbate (15.4%). Independent of the sodium L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats.
• In Vitro:
  Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, L Ascorbic acid sodium salt, Inhibitor, L-Ascorbic acid sodium, LAscorbic acid sodium salt, L-Ascorbic acid, Endogenous Metabolite, EndogenousMetabolite, Apoptosis, Ca channels, Ca2+ channels, Calcium Channel, (+)-Sodium L-ascorbate, CalciumChannel, ReactiveOxygenSpecies, Reactive Oxygen Species, Sodium ascorbate, Sodium L-ascorbate, Vitamin C, Vitamin C sodium, Vitamin C sodium salt

Compound Identifiers

PubChem CID

172005478