KRN2 bromide

SKU: orb1309505

Description

KRN2 bromide

Key Properties

• CAS Number: 1390654-28-0
• MW: 524.38
• Purity: 99.82%
• Formula: C₂₇H₂₃BrFNO₄
• SMILES: [Br-].COc1ccc2c(Cc3ccccc3F)c3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
• Target: Others
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:8 mg/mL (15.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.91 mM)

Bioactivity

• Target IC50:
  NFAT5:100 nM
• In Vivo:
  In DBA/1J mice immunized with bovine type II collagen, KRN2 bromide (3 mg/kg, i.p.) effectively suppresses CIA as well as AIA in which innate immune cells play a predominant role, and decreases the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.
• In Vitro:
  KRN2 bromide inhibits the NF-κB p65 binding to Nfat5 promoter 1 in a dose-dependent manner and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. KRN2 bromide selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, KRN 2, KRN 2 Bromide, KRN2, KRN-2, KRN2 bromide, KRN2 Bromide, KRN-2 Bromide, KRN-2 bromide, inhibit, NFAT5

Compound Identifiers

PubChem CID

71611938