KDM1A Antibody

• Catalog Number: orb1732592
• Category: Antibodies
• Description: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 2F6
• Tested applications: ICC, IP, WB
• Reactivity: Human, Monkey
• Isotype: Mouse IgG1
• Immunogen: Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli.
• Concentration: 1mg/ml
• Dilution range: IP: 1/20; WB: 1/500-1/1000; ICC: 1/50-1/200
• Conjugation: Unconjugated
• MW: Calculated MW: 93 kDa; Observed MW: 110 kDa
• Entrez: 23028
• UniProt ID: O60341
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific
• Note: For research use only
• Expiration Date: 12 months from date of receipt.