KARS Protein, Human, Recombinant (His)

Catalog Number: orb1961204

Catalog Number	orb1961204
Category	Small Molecules
Description	KARS Protein, Human, Recombinant (His)
Purity	98.00%
MW	70-90 KDa, reducing conditions
Biological Activity	Lysine-tRNA ligase, also known as Lysyl-tRNA synthetase, LysRS, KARS and KIAA0070, belongs to the class-II aminoacyl-tRNA synthetase family. The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain, which is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. KARS catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Defects in KARS are the cause of Charcot-Marie-Tooth disease recessive intermediate type B (CMTRIB).
Note	For research use only
Expiration Date	12 months from date of receipt.

Recombinant Human KARS Protein, His Tag [orb1552136]
Purity:
≥90% as determined by SDS-PAGE
Source:
This protein contains the human KARS(Ala2-Val597) was fused with the C-terminal His Tag and expressed in Mammalian cells.
Sizes Available: 100 μg, 50 μg
Human KARS protein (C-His) [orb311883]
Source:
Human Cells
Sizes Available: 1 mg, 500 μg, 50 μg, 10 μg

Purity:	≥90% as determined by SDS-PAGE
Source:	This protein contains the human KARS(Ala2-Val597) was fused with the C-terminal His Tag and expressed in Mammalian cells.