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K-Cadherin Antibody / CDH6

Catalog Number: orb1823373

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb1823373
CategoryAntibodies
DescriptionThis gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. This protein may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.
Species/HostMouse
ClonalityMonoclonal
Clone NumberCDH6/3191
Tested applicationsIHC-P
ReactivityHuman
IsotypeMouse IgG2b, kappa
ImmunogenA recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the Cadherin 6 antibody.
Antibody TypePrimary Antibody
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis Cadherin 6 antibody is available for research use only.
UniProt IDP55285
StorageAliquot the Cadherin 6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
NoteFor research use only
Expiration Date12 months from date of receipt.
K-Cadherin Antibody / CDH6

Analysis of a HuProt (TM) microarray containing more than 19000 full-length human proteins using Cadherin 6 (CDH6) antibody (clone CDH6/3191). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.

K-Cadherin Antibody / CDH6

IHC staining of FFPE human renal cell carcinoma tissue with Cadherin 6 antibody (clone CDH6/3191). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

K-Cadherin Antibody / CDH6

SDS-PAGE analysis of purified, BSA-free Cadherin 6 antibody (clone CDH6/3191) as confirmation of integrity and purity.

  • K-Cadherin Antibody / CDH6 [orb1823372]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg
  • K-Cadherin Antibody / CDH6 [orb1823374]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg
  • K-Cadherin Antibody / CDH6 [orb2635951]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    100 μg
  • K-Cadherin Antibody / CDH6 [orb2635952]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    20 μg
  • K-Cadherin Antibody / CDH6 [orb2635953]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    100 μg