JNK3 inhibitor-4

SKU: orb1744719

Description

JNK3 Inhibitor-4, a potent 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile derivative, demonstrates a strong inhibitory effect on JNK3 with an IC 50 value of 1.0 nM. It exhibits exceptional selectivity against JNK3 when compared to other protein kinases, including isoforms JNK1 (IC 50 = 143.9 nM) and JNK2 (IC 50 = 298.2 nM). Additionally, JNK3 Inhibitor-4 benefits from neuroprotective properties and is predicted to permeate the blood-brain barrier effectively.

Key Properties

• CAS Number: 2409109-65-3
• MW: 477.56
• Formula: C₂₈H₂₇N₇O
• SMILES: C(C#N)C=1N(C(=NC1)C2=CC3=C(C=C2)C=CC=C3)C4=NC(N[C@@H]5CN(C(=O)C6CC6)CCC5)=NC=C4
• Target: Others,JNK

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others,JNK