IWP-2-V2

SKU: orb181261

Description

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. 1, 2, 3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential For the signaling ability and secretion of Wnt proteins.4 IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.4 It has been used to determine which structural features of IWP-2 are essential For impairing Wnt/β-catenin pathway activity.4 For the detailed information of IWP-2-V2, the solubility of IWP-2-V2 in water, the solubility of IWP-2-V2 in DMSO, the solubility of IWP-2-V2 in PBS buffer, the animal experiment (test) of IWP-2-V2, the cell expriment (test) of IWP-2-V2, the in vivo, in vitro and clinical trial test of IWP-2-V2, the EC50, IC50, and Affinity of IWP-2-V2.

Key Properties

• CAS Number: 877618-79-6
• MW: 480.6
• Purity: >98%
• Formula: C₂₃H₂₀N₄O₂S
• SMILES: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3CC5=CC=CC=C5)SCC4

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

18563036