Ivabradine hydrochloride

• Catalog Number: orb1305345
• Category: Small Molecules
• Description: Ivabradine hydrochloride
• CAS Number: 148849-67-6
• Purity: 99.70%
• MW: 505.05
• SMILES: N1(C(=O)Cc2c(CC1)cc(c(c2)OC)OC)CCCN(C)C[C@@H]1c2c(cc(c(c2)OC)OC)C1.Cl
• Formula: C₂₇H₃₇ClN₂O₅
• Biological Activity: Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.