ITGA6 antibody

• Catalog Number: orb153986
• Category: Antibodies
• Description: Rabbit polyclonal antibody to ITGA6. Integrins are alpha / beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outsidein signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (insideout signaling) (1,2).Integrin alpha 6 is a 120 kDa protein with two splice variants, integrin alpha 6, 6A and 6B (3), which function as receptors for laminins on the basal membrane to mediate cellular adhesion events (46). alpha 6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse, Rat
• Isotype: IgG
• Immunogen: Recombinant fusion protein of human Integrin alpha 6 (ITGA6/CD49f)(NP_001073286.1).
• Dilution range: WB: 1:500-2000
• Conjugation: Unconjugated
• MW: 125KDa
• UniProt ID: P23229
• Storage: Store at -20°C. Avoid freeze / thaw cycles.
• Buffer/Preservatives: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
• Alternative names: anti CD49f antibody, anti VLA6 antibody, anti ITGA
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of extracts of various cells using ITGA6 antibody