Isofraxidin

SKU: orb1301356

Description

Isofraxidin, a bioactive coumarin, demonstrates radioprotective effects in leukemia cells via ROS-mitochondrial pathways and alleviates LPS-induced acute lung injury by suppressing COX-2/PGE2. Its analgesic and anti-inflammatory properties are linked to modulating TNF-α and inhibiting p38/ERK1/2 phosphorylation, supporting research in oncology, immunology, and inflammation using in vitro and murine models.

Research Area

Immunology & Inflammation, Neuroscience, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 486-21-5
• MW: 222.19
• Purity: 99.65%
• Formula: C₁₁H₁₀O₅
• SMILES: COc1cc2ccc(=O)oc2c(OC)c1O
• Target: TLR,MMP,COX,p38 MAPK,ERK
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;DMSO:40 mg/mL (180.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERK, ERK1/2, hepatoma, iNOS, Inhibitor, MD-2, Matrix metalloproteinases, invasion, inhibit, Isofraxidin, MMP, MMP-7, Cyclooxygenase, cell, COX, COX-2, 6,8-Dimethoxyumbelliferone, TLR, TLR4, Phytodolor, p38MAPK, p38, p38 MAPK, Toll-like Receptor (TLR)

Compound Identifiers

PubChem CID

5318565