Isoconazole nitrate

SKU: orb1225546

Description

Isoconazole nitrate (Travogen) is an azole antifungal reagent.(In Vitro):Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure.Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 24168-96-5
• MW: 479.14
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₄Cl₄N₂O·HNO₃
• SMILES: O[N+]([O-])=O.ClC1=CC(Cl)=C(C=C1)C(CN1C=CN=C1)OCC1=C(Cl)C=CC=C1Cl
• Target: Others
• Solubility: Ethanol: 4 mg/mL (8.34 mM); DMSO: 41 mg/mL (85.56 mM)

Bioactivity

• In Vitro:
  Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure. Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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