ISCK03

SKU: orb1304190

Description

ISCK03

Research Area

Signal Transduction

Key Properties

• CAS Number: 945526-43-2
• MW: 355.45
• Purity: 98.23%
• Formula: C₁₉H₂₁N₃O₂S
• SMILES: CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-n1ccnc1
• Target: c-Kit
• Solubility: DMSO:50 mg/mL (140.67 mM)

Bioactivity

• In Vivo:
  Administering ISCK03 orally causes a dose-dependent depigmentation of newly regrown hair, a process that reverses upon discontinuing the treatment. Topically applying ISCK03 effectively depigments UV-induced hyperpigmented spots. Fontana-Masson staining analysis reveals a reduction in epidermal melanin in areas treated with ISCK03.
• In Vitro:
  Pretreatment with ISCK03 dose-dependently inhibits SCF-induced c-kit phosphorylation and p44/42 ERK (MAPK) phosphorylation, key components of SCF/c-kit signaling, without affecting HGF-induced phosphorylation of the same ERK proteins. As a specific tyrosine kinase inhibitor of KIT, ISCK03 effectively suppresses the survival of CCDC26-KD cells in low-serum environments, demonstrating dose-dependent sensitivity. While significantly impacting KD cells, reducing their survival to levels comparable with non-KD cells, ISCK03 shows minimal effects on the growth of control K562 and KD clone 3–4 cells in high-serum conditions.
• Cell Research:
  To determine any cytotoxic effects of ISCK03 on 501mel cells, MTT assays are performed with various doses of ISCK03 (1, 5, 10 μM). 501mel cells are cultured with SCF alone (50 ng/mL) or SCF with ISCK03 for 48 h.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCFR, c-Kit, cKit, CD117, inhibit, ISCK 03, ISCK03, ISCK-03, Inhibitor

Compound Identifiers

PubChem CID

3792751