Inulin

SKU: orb1300674

Description

Inulin, a fructosan starch derived from plant tubers and roots, is hydrolyzable to fructose. It is widely used in research as a prebiotic to study gut microbiota, in renal function diagnostics, and as a carrier in pharmaceutical formulations for both in vitro and in vivo studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 9005-80-5
• MW: 490.411
• Purity: ≥95% (May vary between batches)
• Formula: C₁₇H₃₀O₁₆
• SMILES: OC[C@H]1O[C@@](CO)(OC[C@@]2(O[C@H]3O[C@H](O)[C@@H](O)[C@H](O)[C@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O
• Target: Endogenous Metabolite,Others
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL;H2O:95 mg/mL;DMSO:105 mg/mL

Bioactivity

• In Vivo:
  Inulin results in an increase in caecal wt and beta-glucosidase activity and a decrease in caecal pH were observed in rats given inulin-containing diets (with or without B. longum).
• In Vitro:
  Inulin causes (20 g/d and 40 g/d) a significant increase in bifidobacterial counts in feces. Inulin exerts a preferential stimulatory effect on numbers of the health-promoting genus Bifidobacterium, whilst maintaining populations of potential pathogens (Escherichia coli, Clostridium) at relatively low levels. Inulin combined with Bifidobacterium results in more potent inhibition of aberrant crypt foci (ACF) than administration of the two separately, achieving 80% inhibition of small ACF. Inulin is made by a set of linear chains of fructose molecules, with a degree of polymerization (DP) ranging between 3 and 65, it can be fractionated into a slowly fermentable long-chain fraction (DP ranging from 10 to 65, average 25) or in a rapidly fermentable fraction made of oligofructose (DP ranging from 3 to 8, average 4). Long-chain inulin combined with short-chain oligofructose results in larger numbers of caecal, colonic and faecal bacteria of the Clostridium coccoides-Eubacterium rectale cluster than Control in rats, whereas OF alone does not affect this bacterial group in caecum, colon or faeces.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Inulin

Compound Identifiers

PubChem CID

129520965