Integrin beta 3 Antibody

• Catalog Number: orb1730127
• Category: Antibodies
• Description: Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ELISA, IHC, WB
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human ITGB3. AA range:621-670
• Dilution range: WB: 1/500-1/1000; IHC: 1/50-1/100; ELISA: 1/10000
• Conjugation: Unconjugated
• MW: Calculated MW: 87 kDa; Observed MW: 87 kDa
• Entrez: 3690
• UniProt ID: P05106
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: ITGB3; GP3A; Integrin beta-3; Platelet membrane gl
• Note: For research use only
• Expiration Date: 12 months from date of receipt.