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Taccalonolide A
Catalog Number: orb1297196
| Catalog Number | orb1297196 |
|---|---|
| Category | Small Molecules |
| Description | Taccalonolide A |
| Purity | 99.40% |
| MW | 702.74 |
| Biological Activity | Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells. |
| CAS Number | [108885-68-3] |
| Formula | C36H46O14 |
| SMILES | [H][C@@]12[C@H](OC(C)=O)[C@@]3([H])[C@]4([H])[C@@H](O)C(=O)[C@@]5([H])C[C@@H]6O[C@@H]6[C@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(C)[C@@]1([H])[C@H](C)C=C1OC(=O)[C@@](C)(O)[C@]21C |
| Storage | -20°C |
| Note | For research use only |
Taccalonolide B [orb1219390]
> 98% (HPLC)
108885-69-4
660.7
C34H44O13
200 mg, 100 mg, 10 mg, 25 mg, 1 g, 5 mg, 500 mgTaccalonolide A [orb1219391]
> 98% (HPLC)
108885-68-3
702.7
C36H46O14
500 mg, 200 mg, 100 mg, 5 mg, 1 g
