Osunprotafib

• Catalog Number: orb1688337
• Category: Small Molecules
• Description: Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable inhibitor of PTP1B and PTPN2 currently in clinical trials for the treatment of solid tumors. It modulates the tumor microenvironment by boosting natural killer cell and CD8 T cell activity, enhancing anti-tumor immunity through activation of JAK–STAT signaling, and mitigating T cell dysfunction.
• Target: Phosphatase
• Form/Appearance: Powder
• MW: 385.45
• Solubility (25°C): DMSO: 56.2 mg/mL (145.9 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble)
• CAS Number: 2489404-97-7
• Formula: C₁₇H₂₄FN₃O₄S
• SMILES: CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1
• Storage: Powder: -20°C
• Alternative names: Osunprotafib, AC484, AC 484, ABBV-CLS-484
• Research Area: Metabolism Research
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Cas No. 2489404-97-7