Larotaxel

SKU: orb1707097

Description

Larotaxel (XRP9881) is a taxane-based anticancer agent that stabilizes microtubules, inducing apoptotic cell death. It crosses the blood-brain barrier and shows reduced susceptibility to P-glycoprotein efflux. This compound is utilized in preclinical research for studying breast and bladder cancer models, both in vitro and in vivo.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 156294-36-9
• MW: 831.9
• Purity: 99.22%
• Formula: C₄₅H₅₃NO₁₄
• SMILES: [H][C@@]12C[C@@H]3C[C@@]33C(=O)[C@]([H])(OC(C)=O)C4=C(C)[C@@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1
• Target: Apoptosis,P-gp
• Solubility: DMSO:50 mg/mL (60.1 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Larotaxel, Pgp, P-glycoprotein, XRP9881, XRP-9881, XRP 9881

Compound Identifiers

PubChem CID

154805959