Hydroxy-α-sanshool

SKU: orb1685390

Description

Hydroxy-α-sanshool is a natural alkylamide from Szechuan pepper, functioning as a dual agonist for TRPA1 (covalent, EC50 69 µM) and TRPV1 (non-covalent, EC50 1.1 µM). It is a valuable research tool for studying somatosensation, pain mechanisms, and the pharmacological modulation of these ion channels in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 83883-10-7
• MW: 263.38
• Purity: 99.47% (May vary between batches)
• Formula: C₁₆H₂₅NO₂
• SMILES: C\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)(C)O
• Target: Endogenous Metabolite,TRP/TRPV Channel
• Solubility: DMSO:37.5 mg/mL (142.38 mM);10% DMSO+90% Corn Oil:2 mg/mL (7.59 mM)

Bioactivity

• Target IC50:
  TRPA1:69 µM (EC50)|TRPV1:1.1 µM (EC50)

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, Inhibitor, Hydroxyαsanshool, Hydroxy-α-sanshool, Hydroxy α sanshool, Hydroxy-​α-​sanshool, Hydroxy-alpha-sanshool, Hydroxy-a-sanshool, inhibit, Transient receptor potential channels, TRP Channel, TRPA1, TRPChannel, TRPV Channel, TRPVChannel, TRPV1

Compound Identifiers

PubChem CID

10084135