HALOFUGINONE LACTATE

SKU: orb1219325

Description

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS.

Images & Validation

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Key Properties

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CAS Number	82186-71-8
MW	504.8
Purity	>98% (HPLC)
Formula	C₁₉H₂₃BrClN₃O₆
Target	prolyl-tRNA synthetase\|TGF-β

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Disclaimer	For research use only

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Gene Symbol

prolyl-tRNA synthetase|TGF-β

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