Demethylwedelolactone

SKU: orb1301328

Description

Demethylwedelolactone

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 6468-55-9
• MW: 300.22
• Purity: 100.00%
• Formula: C₁₅H₈O₇
• SMILES: Oc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1
• Target: Serine Protease
• Solubility: DMSO:22.5 mg/mL (74.95 mM)

Bioactivity

• Target IC50:
  Trypsin:3.0 μM
• In Vitro:
  Demethylwedelolactone (DWEL) inhibite the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. DWEL reduce the activity and expression of matrix metalloproteinases (MMPs) involved in blockin the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore , DWEL suppresse the metastasis and lung colonization o the tumor cells in the nude mice. DWEL derivatives exert anti-invasive growth effect on breast cancer cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

SerineProtease, Threonine proteases, Serine endopeptidases, Ser/Thr Protease, Serine Protease, Serine proteases, trypsin, Demethylwedelolactone, Inhibitor, inhibit, NF-κB, MMP, ERK, MEK, IkB, IKK

Compound Identifiers

PubChem CID

5489605