D228

SKU: orb2665092

Description

D228 is an orally active anti-inflammatory small molecule derived from Chimonanthus salicifolius. It suppresses lymphocyte activity, modulates the MyD88/TRAF6/p38 pathway, and elevates IL-10, demonstrating therapeutic potential for inflammatory bowel disease (IBD) in research models.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2676188-98-8
• MW: 484.45
• Purity: 99.91%
• Formula: C₂₂H₂₈O₁₂
• SMILES: O([C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)C=2C(=O)C(=C(C)C)OC2C
• Target: MyD88,IL Receptor,p38 MAPK
• Solubility: DMSO:40 mg/mL (82.57 mM)

Bioactivity

• In Vivo:
  In the DSS-induced chronic IBD model in C57BL/6 mice, oral administration of D228 (40 mg/kg/day for 14 consecutive days) significantly alleviated body weight loss and colon shortening.
• In Vitro:
  D228 effectively inhibits Concanavalin A (ConA)-induced proliferation of human T lymphocytes, with an IC₅₀ value of 42.85 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D 228

Compound Identifiers

PubChem CID

156516634