CL-82198

SKU: orb1308445

Description

CL-82198 is a selective MMP-13 inhibitor that binds the enzyme's S1' pocket, providing specificity to block cartilage degradation in osteoarthritis models. It is a valuable research tool for investigating OA pathogenesis and potential therapeutics in both in vitro and in vivo studies.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 307002-71-7
• MW: 302.37
• Purity: 95.91% (May vary between batches)
• Formula: C₁₇H₂₂N₂O₃
• SMILES: O=C(NCCCCN1CCOCC1)c1cc2ccccc2o1
• Target: MMP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.23 mM);DMSO:100 mg/mL (330.72 mM)

Bioactivity

• In Vivo:
  CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) treatment avoids and decelerates MLI-induced osteoarthritis progression.
• In Vitro:
  CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells. CL-82198 (10 μM; 24 hours) obviously reduces LS174 cell migration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Matrix metalloproteinases, MMP, MMP-13, inhibit, Inhibitor, CL 82198, CL82198, CL-82198

Compound Identifiers

PubChem CID

2777