Avenanthramide C

SKU: orb2802060

Description

Avenanthramide C is a bioactive alkaloid with antioxidant and anti-inflammatory properties. It modulates key pathways in neurodegeneration and otoprotection, as evidenced by in vivo studies showing reduced Alzheimer's-like deficits and attenuated hearing loss in animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 116764-15-9
• MW: 315.28
• Purity: 99.40%
• Formula: C₁₆H₁₃NO₆
• SMILES: N(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=C(C(O)=O)C=C(O)C=C2
• Target: Caspase,Interleukin,TNF,Adrenergic Receptor,AMPK,IL Receptor,Bcl-2 Family
• Solubility: DMSO:40 mg/mL (126.87 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.34 mM)

Bioactivity

• In Vivo:
  In an LPS-induced acute inflammation mouse model, a single intraperitoneal injection of Avenanthramide C (20 mg/kg) significantly reduces IL-1β levels in peritoneal fluid and downregulates NLRP3 and GSDMD expression, demonstrating its anti-inflammatory and anti-pyroptotic effects in vivo.
• In Vitro:
  In RAW264.7 macrophages, Avenanthramide C (0-50 μM, 24 h) significantly inhibits LPS/ATP-induced ROS production, mitochondrial membrane potential loss, membrane permeability increase, and IL-1β secretion. Avenanthramide C also downregulates the expression of NLRP3, Caspase-1, GSDMD, and IL-1β proteins, indicating suppression of ROS-mediated mitochondrial damage and pyroptosis via the PI3K/Akt pathway.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11723200