Alectinib hydrochloride

SKU: orb1298976

Description

Alectinib hydrochloride is a potent and selective oral ALK inhibitor with an IC50 of 1.9 nM. It is widely used in preclinical research for studying non-small cell lung cancer (NSCLC), demonstrating efficacy in both cellular assays and in vivo models of ALK-driven tumors.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1256589-74-8
• MW: 519.08
• Purity: 99.74%
• Formula: C₃₀H₃₅ClN₄O₂
• SMILES: Cl.CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1
• Target: ALK
• Solubility: DMSO:6.25 mg/mL (12.04 mM)

Bioactivity

• Target IC50:
  ALK:1.9 nM
• In Vivo:
  Alectinib hydrochloride(CH5424802), a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo
• Animal Research:
  Animal Model:SCID or nude mice bearing NCI-H2228 cells. Dosage:0.2 mg/kg, 0.6 mg/kg, 2 mg/kg, 6 mg/kg, 20 mg/kg. Administration:Oral administration; once daily; for 11 days

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD246, Cluster of differentiation 246, CH 5424802, CH5424802, CH-5424802, CH5424802 (Hydrochloride), Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), AF802, AF-802, AF-802 (Hydrochloride), AF 802, Alectinib, Alectinib hydrochloride, Alectinib Hydrochloride, ALK, ALK tyrosine kinase receptor, inhibit, Inhibitor, RO5424802, RO-5424802, RO5424802 (Hydrochloride), RO 5424802

Compound Identifiers

PubChem CID

53239799