AKE-72

SKU: orb2281171

Description

AKE-72 is a small molecule pan-BCR-ABL inhibitor that suppresses the growth of Ba/F3 cells harboring native or T315I-mutant BCR-ABL. It is a research tool for studying kinase resistance mechanisms in chronic myeloid leukemia (CML) models, applicable in both in vitro and in vivo experimental settings.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2566525-18-4
• MW: 546.59
• Purity: 98.30%
• Formula: C₃₀H₂₉F₃N₆O
• SMILES: O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C=3C=CC=C(C#CC4=CC=CC=5NN=C(N)C45)C3
• Target: Bcr-Abl

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BcrAbl, BCR-ABL, AKE72

Compound Identifiers

PubChem CID

155386679